Mirror bacteria, call for stop of research

A group of 38 internationally renowned scientists has issued a joint statement that urges a halt to research efforts to develop so-called mirror bacteria, synthetic organisms of molecules mirroring those found in nature, citing concerns about potential unintended consequences. In their appeal, published in the journal Science and supported by a 300-page technical report, the experts note that while such microorganisms do not yet represent reality, they could pose a serious threat to global health if their mirror-like molecular structure is not recognised by the immune defences of humans and animals in future. Specifically, the mirror bacteria can potentially evade predation by natural enemies, including phages and protists. If they proliferate unchecked in ecosystems, there is an inherent risk of infection to humans, animals, and plants, according to Patrick Cai of the University of Manchester, one of the signatories of the appeal and an expert in synthetic genomics and biosafety. To avert this potential global health crisis, scientists call for a public debate involving the global scientific community, research funders, and policymakers. They plan to hold events in 2025 to review the findings and discuss measures that can be taken to prevent potential risks.